Drug interactions
Thiothixene + Trazodone
Severity: Moderate
Thiothixene and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, and each can cause orthostatic hypotension and prolong the QT interval. Combined use can increase drowsiness, hypotension and arrhythmia risk.
What this interaction means in plain words
Thiothixene and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, alpha-1 blockade and possible additive QT prolongation.
What to do
Monitor blood pressure, sedation and ECG, especially with other QT-prolonging drugs or electrolyte disturbances. Start at low doses and titrate slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Thiothixene with Trazodone?
MediHelp rates the interaction as moderate. Thiothixene and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, and each can cause orthostatic hypotension and prolong the QT interval. Combined use can increase drowsiness, hypotension and arrhythmia risk.
How serious is the interaction between Thiothixene and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, sedation and ECG, especially with other QT-prolonging drugs or electrolyte disturbances. Start at low doses and titrate slowly.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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