Drug interactions
Thiothixene + Trimipramine
Severity: Moderate
Thiothixene and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sedating and anticholinergic, and each can affect cardiac conduction. Together they may increase drowsiness, anticholinergic effects, and lower seizure threshold.
What this interaction means in plain words
Thiothixene and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant, anticholinergic and seizure-threshold-lowering effects; thiothixene may also compete for CYP2D6.
What to do
Use the lowest effective doses and monitor sedation, anticholinergic effects and ECG in at-risk patients. Warn about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Thiothixene with Trimipramine?
MediHelp rates the interaction as moderate. Thiothixene and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sedating and anticholinergic, and each can affect cardiac conduction. Together they may increase drowsiness, anticholinergic effects, and lower seizure threshold.
How serious is the interaction between Thiothixene and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, anticholinergic effects and ECG in at-risk patients. Warn about driving.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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