Drug interactions
Ticagrelor + Topotecan
Severity: Moderate
Ticagrelor and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor inhibits P-gp and may increase topotecan exposure, particularly oral topotecan, raising the risk of myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Ticagrelor and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ticagrelor belongs to Cardiovascular; Topotecan belongs to Oncology.
Why it happens
P-gp inhibition increases topotecan absorption and reduces its efflux.
What to do
Avoid ticagrelor with oral topotecan where possible. With intravenous topotecan, monitor blood counts closely and adjust the dose for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Ticagrelor with Topotecan?
MediHelp rates the interaction as moderate. Ticagrelor and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticagrelor inhibits P-gp and may increase topotecan exposure, particularly oral topotecan, raising the risk of myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Ticagrelor and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ticagrelor with oral topotecan where possible. With intravenous topotecan, monitor blood counts closely and adjust the dose for toxicity.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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