Drug interactions
Tinidazole + Verapamil
Severity: Minor
Tinidazole and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and tinidazole is partly metabolized by this enzyme, so tinidazole exposure may rise modestly. Because tinidazole is given for short courses and has a wide margin of safety, the clinical consequence is usually limited to more frequent gastrointestinal or neurological adverse effects.
What this interaction means in plain words
Tinidazole and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tinidazole belongs to Anti Parasitic; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4-mediated metabolism of tinidazole, increasing its plasma concentration.
What to do
No dose change is normally needed; counsel the patient to report nausea, dizziness or neurological symptoms during the tinidazole course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tinidazole and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Tinidazole with Verapamil?
MediHelp rates the interaction as minor. Tinidazole and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil inhibits CYP3A4 and tinidazole is partly metabolized by this enzyme, so tinidazole exposure may rise modestly. Because tinidazole is given for short courses and has a wide margin of safety, the clinical consequence is usually limited to more frequent gastrointestinal or neurological adverse effects.
How serious is the interaction between Tinidazole and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; counsel the patient to report nausea, dizziness or neurological symptoms during the tinidazole course.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
