Drug interactions
Tinidazole + Voxelotor
Severity: Minor
Tinidazole and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may modestly increase concentrations of CYP3A4 substrates such as tinidazole. The effect is expected to be small given tinidazole's wide therapeutic margin.
What this interaction means in plain words
Tinidazole and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tinidazole belongs to Anti Parasitic; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, slightly reducing tinidazole metabolism.
What to do
No dose adjustment is usually needed; be aware of possible increased tinidazole adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Tinidazole with Voxelotor?
MediHelp rates the interaction as minor. Tinidazole and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor inhibits CYP3A4 and may modestly increase concentrations of CYP3A4 substrates such as tinidazole. The effect is expected to be small given tinidazole's wide therapeutic margin.
How serious is the interaction between Tinidazole and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; be aware of possible increased tinidazole adverse effects.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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