Drug interactions
Tiotropium + Umeclidinium-vilanterol
Severity: Major
Tiotropium and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both umeclidinium and tiotropium are long-acting muscarinic antagonists, so combining them duplicates therapy. This increases anticholinergic effects such as dry mouth, urinary retention, tachycardia and glaucoma worsening, without clear added benefit.
What this interaction means in plain words
Tiotropium and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tiotropium belongs to Respiratory; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism from two long-acting anticholinergics.
What to do
Avoid concurrent use; keep only one long-acting muscarinic antagonist. Review the inhaler regimen and stop the duplicate agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Tiotropium
Frequently asked questions
Can I take Tiotropium with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Tiotropium and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both umeclidinium and tiotropium are long-acting muscarinic antagonists, so combining them duplicates therapy. This increases anticholinergic effects such as dry mouth, urinary retention, tachycardia and glaucoma worsening, without clear added benefit.
How serious is the interaction between Tiotropium and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; keep only one long-acting muscarinic antagonist. Review the inhaler regimen and stop the duplicate agent.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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