Drug interactions
Tiotropium + Ziprasidone
Severity: Minor
Tiotropium and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone has some anticholinergic activity, so combining it with tiotropium could add modestly to anticholinergic effects such as dry mouth, constipation or urinary retention. Because inhaled tiotropium is minimally absorbed, the effect is usually small.
What this interaction means in plain words
Tiotropium and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tiotropium belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Possible additive antimuscarinic effects; systemic tiotropium exposure is low.
What to do
Monitor for anticholinergic symptoms such as urinary retention or constipation, particularly in older patients or those with glaucoma or prostatic hypertrophy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tiotropium
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Tiotropium with Ziprasidone?
MediHelp rates the interaction as minor. Tiotropium and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ziprasidone has some anticholinergic activity, so combining it with tiotropium could add modestly to anticholinergic effects such as dry mouth, constipation or urinary retention. Because inhaled tiotropium is minimally absorbed, the effect is usually small.
How serious is the interaction between Tiotropium and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms such as urinary retention or constipation, particularly in older patients or those with glaucoma or prostatic hypertrophy.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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