Drug interactions
Tiotropium-olodaterol + Umeclidinium bromide
Severity: Moderate
Tiotropium-olodaterol and Umeclidinium bromide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are inhaled long-acting muscarinic antagonists, so using them together duplicates therapy and increases anticholinergic adverse effects. These include dry mouth, urinary retention, worsening of glaucoma and tachycardia, with no added bronchodilator benefit expected.
What this interaction means in plain words
Tiotropium-olodaterol and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism from two drugs of the same class.
What to do
Avoid combining two long-acting muscarinic antagonists and keep only one in the regimen. If both were prescribed in error, stop one and review the patient for anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Tiotropium-olodaterol with Umeclidinium bromide?
MediHelp rates the interaction as moderate. Tiotropium-olodaterol and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are inhaled long-acting muscarinic antagonists, so using them together duplicates therapy and increases anticholinergic adverse effects. These include dry mouth, urinary retention, worsening of glaucoma and tachycardia, with no added bronchodilator benefit expected.
How serious is the interaction between Tiotropium-olodaterol and Umeclidinium bromide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two long-acting muscarinic antagonists and keep only one in the regimen. If both were prescribed in error, stop one and review the patient for anticholinergic effects.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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