Drug interactions
Tipranavir + Tolterodine
Severity: Moderate
Tipranavir and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, can raise tolterodine exposure because tolterodine is cleared partly by CYP3A4, especially in patients who are poor CYP2D6 metabolizers. Higher levels increase anticholinergic effects and the risk of QT prolongation.
What this interaction means in plain words
Tipranavir and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tipranavir belongs to Anti Virals; Tolterodine belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated metabolism of tolterodine by the tipranavir/ritonavir combination, although tipranavir also has mixed induction effects.
What to do
Limit tolterodine to 1 mg twice daily when it is given with strong CYP3A4 inhibitors and monitor for anticholinergic effects and palpitations. Consider an alternative agent in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tipranavir with Tolterodine?
MediHelp rates the interaction as moderate. Tipranavir and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, can raise tolterodine exposure because tolterodine is cleared partly by CYP3A4, especially in patients who are poor CYP2D6 metabolizers. Higher levels increase anticholinergic effects and the risk of QT prolongation.
How serious is the interaction between Tipranavir and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit tolterodine to 1 mg twice daily when it is given with strong CYP3A4 inhibitors and monitor for anticholinergic effects and palpitations. Consider an alternative agent in patients with QT risk factors.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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