Drug interactions
Tipranavir + Vinorelbine
Severity: Major
Tipranavir and Vinorelbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted tipranavir strongly inhibits CYP3A4 and may increase vinorelbine exposure. This raises the risk of severe neutropenia and neurotoxicity.
What this interaction means in plain words
Tipranavir and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tipranavir belongs to Anti Virals; Vinorelbine belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated vinorelbine metabolism by ritonavir-boosted tipranavir.
What to do
Avoid the combination if possible. If necessary, monitor blood counts and neurotoxicity closely and reduce the vinorelbine dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinorelbine
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tipranavir with Vinorelbine?
MediHelp rates the interaction as major. Tipranavir and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir-boosted tipranavir strongly inhibits CYP3A4 and may increase vinorelbine exposure. This raises the risk of severe neutropenia and neurotoxicity.
How serious is the interaction between Tipranavir and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, monitor blood counts and neurotoxicity closely and reduce the vinorelbine dose as needed.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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