Drug interactions
Tizanidine + Trandolapril
Severity: Moderate
Tizanidine and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine is an alpha-2 agonist that lowers blood pressure, and trandolapril is an ACE inhibitor with antihypertensive effect. Taken together they can produce additive hypotension, with dizziness or fainting especially at treatment initiation or dose increases.
What this interaction means in plain words
Tizanidine and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tizanidine belongs to Musculoskeletal; Trandolapril belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering through central sympatholytic action and inhibition of the renin-angiotensin system.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Start tizanidine at a low dose and titrate slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Tizanidine with Trandolapril?
MediHelp rates the interaction as moderate. Tizanidine and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine is an alpha-2 agonist that lowers blood pressure, and trandolapril is an ACE inhibitor with antihypertensive effect. Taken together they can produce additive hypotension, with dizziness or fainting especially at treatment initiation or dose increases.
How serious is the interaction between Tizanidine and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Start tizanidine at a low dose and titrate slowly.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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