Drug interactions
Tizanidine + Triamterene
Severity: Minor
Tizanidine and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine can lower blood pressure, and triamterene is a diuretic that reduces volume and blood pressure. Combined use may cause additive hypotension and dizziness, mainly in volume-depleted or older patients.
What this interaction means in plain words
Tizanidine and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tizanidine belongs to Musculoskeletal; Triamterene belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from central alpha-2 agonism and diuretic-induced volume reduction.
What to do
Check blood pressure and orthostatic symptoms after starting tizanidine or changing doses, and reduce the tizanidine dose if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Tizanidine with Triamterene?
MediHelp rates the interaction as minor. Tizanidine and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tizanidine can lower blood pressure, and triamterene is a diuretic that reduces volume and blood pressure. Combined use may cause additive hypotension and dizziness, mainly in volume-depleted or older patients.
How serious is the interaction between Tizanidine and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure and orthostatic symptoms after starting tizanidine or changing doses, and reduce the tizanidine dose if symptomatic hypotension develops.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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