Drug interactions
Tobramycin + Torsemide
Severity: Major
Tobramycin and Torsemide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Torsemide with tobramycin raises the risk of hearing and balance damage and of kidney injury, especially with dehydration. Hearing loss may be permanent.
What this interaction means in plain words
Tobramycin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tobramycin belongs to Anti Bacterial; Torsemide belongs to Cardiovascular.
Why it happens
Additive ototoxicity and nephrotoxicity, with diuretic volume depletion raising aminoglycoside exposure.
What to do
Avoid if possible; otherwise maintain hydration and monitor renal function, tobramycin concentrations and hearing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Other interactions of Torsemide
Frequently asked questions
Can I take Tobramycin with Torsemide?
MediHelp rates the interaction as major. Tobramycin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Torsemide with tobramycin raises the risk of hearing and balance damage and of kidney injury, especially with dehydration. Hearing loss may be permanent.
How serious is the interaction between Tobramycin and Torsemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise maintain hydration and monitor renal function, tobramycin concentrations and hearing.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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