Drug interactions
Tocilizumab + Trastuzumab deruxtecan
Severity: Moderate
Tocilizumab and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan commonly causes neutropenia and tocilizumab can lower neutrophil counts and impair infection defences. Combined use may increase the risk of serious infection.
What this interaction means in plain words
Tocilizumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tocilizumab belongs to Musculoskeletal; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppressive and immunosuppressive effects; no specific pharmacokinetic interaction is known.
What to do
Monitor neutrophil counts regularly and assess promptly for infection. Adjust or hold therapy according to neutropenia severity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Tocilizumab with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Tocilizumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan commonly causes neutropenia and tocilizumab can lower neutrophil counts and impair infection defences. Combined use may increase the risk of serious infection.
How serious is the interaction between Tocilizumab and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts regularly and assess promptly for infection. Adjust or hold therapy according to neutropenia severity.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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