Drug interactions
Tofacitinib + Triclabendazole
Severity: Minor
Tofacitinib and Triclabendazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole and its metabolites inhibit CYP2C19 and may increase tofacitinib levels. Because it is given as a short course, the effect is likely small.
What this interaction means in plain words
Tofacitinib and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tofacitinib belongs to Musculoskeletal; Triclabendazole belongs to Anti Parasitic.
Why it happens
Inhibition of CYP2C19 reduces tofacitinib clearance.
What to do
No dose adjustment is usually needed; monitor for tofacitinib adverse effects during the course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Triclabendazole
Frequently asked questions
Can I take Tofacitinib with Triclabendazole?
MediHelp rates the interaction as minor. Tofacitinib and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triclabendazole and its metabolites inhibit CYP2C19 and may increase tofacitinib levels. Because it is given as a short course, the effect is likely small.
How serious is the interaction between Tofacitinib and Triclabendazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for tofacitinib adverse effects during the course.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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