Drug interactions
Tolazamide + Tolfenamic acid
Severity: Moderate
Tolazamide and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid may potentiate sulfonylurea effects, causing hypoglycemia in some patients. Evidence mainly derives from other NSAIDs.
What this interaction means in plain words
Tolazamide and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolazamide belongs to Endocrine; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and altered renal prostaglandin effects; the mechanism is not firmly established for tolfenamic acid.
What to do
Monitor blood glucose when starting or stopping tolfenamic acid and adjust the tolazamide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Tolazamide with Tolfenamic acid?
MediHelp rates the interaction as moderate. Tolazamide and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid may potentiate sulfonylurea effects, causing hypoglycemia in some patients. Evidence mainly derives from other NSAIDs.
How serious is the interaction between Tolazamide and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping tolfenamic acid and adjust the tolazamide dose if needed.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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