Drug interactions
Tolbutamide + Tranylcypromine
Severity: Moderate
Tolbutamide and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can potentiate the glucose-lowering effect of sulfonylureas and may cause hypoglycemia. The risk is greatest when tranylcypromine is started or the dose is raised.
What this interaction means in plain words
Tolbutamide and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolbutamide belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibitors may enhance insulin secretion or sensitivity, but the exact mechanism is not well established.
What to do
Monitor blood glucose closely when starting or stopping tranylcypromine. Lower the tolbutamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Tolbutamide with Tranylcypromine?
MediHelp rates the interaction as moderate. Tolbutamide and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can potentiate the glucose-lowering effect of sulfonylureas and may cause hypoglycemia. The risk is greatest when tranylcypromine is started or the dose is raised.
How serious is the interaction between Tolbutamide and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping tranylcypromine. Lower the tolbutamide dose if hypoglycemia occurs.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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