Drug interactions
Brexpiprazole + Tolcapone
Severity: Moderate
Brexpiprazole and Tolcapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole, a dopamine D2 partial agonist, may oppose the dopaminergic effect of tolcapone used in Parkinson disease, potentially worsening motor symptoms. Tolcapone can also cause somnolence and dizziness, which may add to the sedative effects of brexpiprazole.
What this interaction means in plain words
Brexpiprazole and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Tolcapone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at D2 receptors plus additive CNS effects.
What to do
Monitor motor function in Parkinson disease patients and for excessive sedation. Review the need for the antipsychotic or consider an agent with less D2 blockade if motor symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Tolcapone + Tranylcypromine Contraindicated
- Metoclopramide + Tolcapone Major
- Apomorphine + Tolcapone Moderate
- Asenapine + Tolcapone Moderate
Frequently asked questions
Can I take Brexpiprazole with Tolcapone?
MediHelp rates the interaction as moderate. Brexpiprazole and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole, a dopamine D2 partial agonist, may oppose the dopaminergic effect of tolcapone used in Parkinson disease, potentially worsening motor symptoms. Tolcapone can also cause somnolence and dizziness, which may add to the sedative effects of brexpiprazole.
How serious is the interaction between Brexpiprazole and Tolcapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor function in Parkinson disease patients and for excessive sedation. Review the need for the antipsychotic or consider an agent with less D2 blockade if motor symptoms worsen.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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