Drug interactions
Tolcapone + Warfarin
Severity: Moderate
Tolcapone and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clinical data on combining tolcapone with warfarin are limited. Changes in anticoagulant effect cannot be excluded, and an unrecognized INR shift could lead to bleeding or loss of anticoagulation.
What this interaction means in plain words
Tolcapone and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolcapone belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
Why it happens
No clear mechanism is established; a pharmacokinetic or protein-binding effect has not been well characterized.
What to do
Check INR more often when tolcapone is started or stopped. Adjust the warfarin dose according to INR results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tolcapone and Warfarin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Tolcapone + Tranylcypromine Contraindicated
- Metoclopramide + Tolcapone Major
- Apomorphine + Tolcapone Moderate
- Asenapine + Tolcapone Moderate
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Tolcapone with Warfarin?
MediHelp rates the interaction as moderate. Tolcapone and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clinical data on combining tolcapone with warfarin are limited. Changes in anticoagulant effect cannot be excluded, and an unrecognized INR shift could lead to bleeding or loss of anticoagulation.
How serious is the interaction between Tolcapone and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more often when tolcapone is started or stopped. Adjust the warfarin dose according to INR results.
What other medicines interact with Tolcapone?
MediHelp also lists interactions of Tolcapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Tolcapone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
