Drug interactions
Tolfenamic acid + Vancomycin
Severity: Moderate
Tolfenamic acid and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can decrease renal perfusion and may raise vancomycin concentrations, increasing the risk of nephrotoxicity. Evidence comes mainly from neonates exposed to NSAIDs.
What this interaction means in plain words
Tolfenamic acid and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolfenamic acid belongs to Musculoskeletal; Vancomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced reduction in renal blood flow lowers vancomycin renal clearance.
What to do
Monitor serum creatinine and vancomycin levels, adjusting the dose. Avoid NSAIDs in patients with renal impairment or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Tolfenamic acid with Vancomycin?
MediHelp rates the interaction as moderate. Tolfenamic acid and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can decrease renal perfusion and may raise vancomycin concentrations, increasing the risk of nephrotoxicity. Evidence comes mainly from neonates exposed to NSAIDs.
How serious is the interaction between Tolfenamic acid and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and vancomycin levels, adjusting the dose. Avoid NSAIDs in patients with renal impairment or dehydration.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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