Drug interactions
Tolvaptan + Voriconazole
Severity: Contraindicated
Tolvaptan and Voriconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can markedly increase tolvaptan exposure, which may cause excessively rapid aquaresis and overly fast sodium correction. Tolvaptan labeling contraindicates strong CYP3A4 inhibitors.
What this interaction means in plain words
Tolvaptan and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Tolvaptan belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated tolvaptan metabolism.
What to do
Do not coadminister; use an alternative antifungal or hold tolvaptan during treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Tolvaptan with Voriconazole?
MediHelp rates the interaction as contraindicated. Tolvaptan and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole can markedly increase tolvaptan exposure, which may cause excessively rapid aquaresis and overly fast sodium correction. Tolvaptan labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Tolvaptan and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antifungal or hold tolvaptan during treatment.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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