Drug interactions
Topotecan + Trilaciclib
Severity: Minor
Topotecan and Trilaciclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits renal transporters OCT2, MATE1 and MATE2-K, which may reduce renal secretion of drugs handled by these pathways. The direction suggested for topotecan is uncertain, and the role of these transporters in topotecan clearance is not well established. Trilaciclib is also given before chemotherapy to protect against myelosuppression, and topotecan is among regimens for which it is used.
What this interaction means in plain words
Topotecan and Trilaciclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Topotecan belongs to Oncology; Trilaciclib belongs to Oncology.
Why it happens
Possible inhibition of renal organic cation transporters; the clinical relevance for topotecan is not established.
What to do
Monitor blood counts and renal function as usual during topotecan therapy; no specific dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Trilaciclib
Frequently asked questions
Can I take Topotecan with Trilaciclib?
MediHelp rates the interaction as minor. Topotecan and Trilaciclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trilaciclib inhibits renal transporters OCT2, MATE1 and MATE2-K, which may reduce renal secretion of drugs handled by these pathways. The direction suggested for topotecan is uncertain, and the role of these transporters in topotecan clearance is not well established. Trilaciclib is also given before chemotherapy to protect against myelosuppression, and topotecan is among regimens for which it is used.
How serious is the interaction between Topotecan and Trilaciclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function as usual during topotecan therapy; no specific dose change is needed.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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