Drug interactions
Tramadol + Triclofos
Severity: Moderate
Tramadol and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic whose active metabolite trichloroethanol causes CNS depression. Together with tramadol it may cause excessive sedation and respiratory depression.
What this interaction means in plain words
Tramadol and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Reduce doses as needed and monitor sedation and respiratory rate, especially in children and elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Tramadol with Triclofos?
MediHelp rates the interaction as moderate. Tramadol and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic whose active metabolite trichloroethanol causes CNS depression. Together with tramadol it may cause excessive sedation and respiratory depression.
How serious is the interaction between Tramadol and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce doses as needed and monitor sedation and respiratory rate, especially in children and elderly patients.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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