Drug interactions
Tramadol + Trifluoperazine
Severity: Moderate
Tramadol and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tramadol with trifluoperazine can increase drowsiness and impair psychomotor performance. Seizure threshold may also be lowered by both drugs.
What this interaction means in plain words
Tramadol and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive lowering of the seizure threshold.
What to do
Start with low doses and monitor for sedation, hypotension and seizures. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Tramadol with Trifluoperazine?
MediHelp rates the interaction as moderate. Tramadol and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tramadol with trifluoperazine can increase drowsiness and impair psychomotor performance. Seizure threshold may also be lowered by both drugs.
How serious is the interaction between Tramadol and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor for sedation, hypotension and seizures. Advise against driving until the response is known.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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