Drug interactions
Tramadol + Yohimbine
Severity: Moderate
Tramadol and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist with stimulant effects and tramadol is an opioid with serotonergic and noradrenergic activity. The combination could theoretically cause agitation, hypertension or lowered seizure threshold, and the net effect on sedation is unpredictable.
What this interaction means in plain words
Tramadol and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS effects with possible additive noradrenergic stimulation; the mechanism is not well established.
What to do
Monitor blood pressure, heart rate, agitation and seizure activity. Avoid use of yohimbine in patients on tramadol who have seizure risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Tramadol with Yohimbine?
MediHelp rates the interaction as moderate. Tramadol and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist with stimulant effects and tramadol is an opioid with serotonergic and noradrenergic activity. The combination could theoretically cause agitation, hypertension or lowered seizure threshold, and the net effect on sedation is unpredictable.
How serious is the interaction between Tramadol and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, agitation and seizure activity. Avoid use of yohimbine in patients on tramadol who have seizure risk.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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