Drug interactions
Tranylcypromine + Ziprasidone
Severity: Moderate
Tranylcypromine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone has serotonergic and dopamine-blocking activity, so combining it with an MAO inhibitor raises the theoretical risk of serotonin toxicity or neuroleptic malignant syndrome. Ziprasidone also prolongs the QT interval, which adds to its own cardiac risk.
What this interaction means in plain words
Tranylcypromine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tranylcypromine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects of MAO inhibition and ziprasidone's serotonin reuptake inhibition and receptor antagonism.
What to do
Monitor for hyperthermia, rigidity, clonus and autonomic instability. Check baseline ECG and electrolytes if risk factors for QT prolongation exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Tranylcypromine with Ziprasidone?
MediHelp rates the interaction as moderate. Tranylcypromine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone has serotonergic and dopamine-blocking activity, so combining it with an MAO inhibitor raises the theoretical risk of serotonin toxicity or neuroleptic malignant syndrome. Ziprasidone also prolongs the QT interval, which adds to its own cardiac risk.
How serious is the interaction between Tranylcypromine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, clonus and autonomic instability. Check baseline ECG and electrolytes if risk factors for QT prolongation exist.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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