Drug interactions
Trastuzumab deruxtecan + Tretinoin
Severity: Minor
Trastuzumab deruxtecan and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan causes neutropenia and interstitial lung disease; systemic tretinoin has its own toxicities, so combined use may increase infection and pulmonary risk. There is no established direct interaction.
What this interaction means in plain words
Trastuzumab deruxtecan and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Trastuzumab deruxtecan belongs to Oncology; Tretinoin belongs to Dermatology.
Why it happens
Additive myelosuppressive and toxic effects; no specific pharmacokinetic mechanism established.
What to do
Monitor blood counts and respiratory symptoms if both are given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Trastuzumab deruxtecan with Tretinoin?
MediHelp rates the interaction as minor. Trastuzumab deruxtecan and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trastuzumab deruxtecan causes neutropenia and interstitial lung disease; systemic tretinoin has its own toxicities, so combined use may increase infection and pulmonary risk. There is no established direct interaction.
How serious is the interaction between Trastuzumab deruxtecan and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and respiratory symptoms if both are given.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
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