Drug interactions
Trastuzumab deruxtecan + Vincristine
Severity: Moderate
Trastuzumab deruxtecan and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause neutropenia, so combined use may increase the frequency and severity of infections. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
What this interaction means in plain words
Trastuzumab deruxtecan and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trastuzumab deruxtecan belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Additive myelosuppression from the topoisomerase I payload and vincristine.
What to do
Monitor complete blood counts frequently and treat febrile neutropenia promptly. Consider dose delays or reductions for severe neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Trastuzumab deruxtecan with Vincristine?
MediHelp rates the interaction as moderate. Trastuzumab deruxtecan and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause neutropenia, so combined use may increase the frequency and severity of infections. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
How serious is the interaction between Trastuzumab deruxtecan and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and treat febrile neutropenia promptly. Consider dose delays or reductions for severe neutropenia.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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