Drug interactions
Trastuzumab deruxtecan + Vinorelbine
Severity: Moderate
Trastuzumab deruxtecan and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause neutropenia. Combined treatment may increase the incidence and severity of neutropenia and febrile neutropenia, raising infection risk.
What this interaction means in plain words
Trastuzumab deruxtecan and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trastuzumab deruxtecan belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Additive myelosuppression from the cytotoxic topoisomerase I inhibitor payload and vinorelbine.
What to do
Monitor complete blood counts frequently. Delay or reduce doses according to neutrophil counts and treat febrile neutropenia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Trastuzumab deruxtecan with Vinorelbine?
MediHelp rates the interaction as moderate. Trastuzumab deruxtecan and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause neutropenia. Combined treatment may increase the incidence and severity of neutropenia and febrile neutropenia, raising infection risk.
How serious is the interaction between Trastuzumab deruxtecan and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently. Delay or reduce doses according to neutrophil counts and treat febrile neutropenia promptly.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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