Drug interactions
Trazodone + Trifluoperazine
Severity: Major
Trazodone and Trifluoperazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both trifluoperazine and trazodone can prolong the QT interval and cause sedation and hypotension. Combined use increases the risk of ventricular arrhythmia.
What this interaction means in plain words
Trazodone and Trifluoperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation with additive sedative and hypotensive effects.
What to do
Avoid if possible; if used, obtain a baseline ECG, correct electrolytes and monitor QTc and orthostatic blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Trazodone with Trifluoperazine?
MediHelp rates the interaction as major. Trazodone and Trifluoperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both trifluoperazine and trazodone can prolong the QT interval and cause sedation and hypotension. Combined use increases the risk of ventricular arrhythmia.
How serious is the interaction between Trazodone and Trifluoperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used, obtain a baseline ECG, correct electrolytes and monitor QTc and orthostatic blood pressure.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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