Drug interactions
Trazodone + Triprolidine
Severity: Moderate
Trazodone and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, so combined use may cause increased drowsiness, dizziness and impaired alertness. Orthostatic hypotension from trazodone may add to the risk of falls.
What this interaction means in plain words
Trazodone and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trazodone belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression through H1 and alpha-1 receptor blockade.
What to do
Counsel on sedation and monitor older patients for falls. Use a non-sedating antihistamine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Trazodone with Triprolidine?
MediHelp rates the interaction as moderate. Trazodone and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, so combined use may cause increased drowsiness, dizziness and impaired alertness. Orthostatic hypotension from trazodone may add to the risk of falls.
How serious is the interaction between Trazodone and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and monitor older patients for falls. Use a non-sedating antihistamine if needed.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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