Drug interactions
Trazodone + Yohimbe
Severity: Moderate
Trazodone and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine, the active alkaloid in yohimbe, is an alpha-2 antagonist that raises noradrenergic activity and blood pressure, while trazodone blocks alpha-1 receptors and can lower it. Together they may cause unpredictable blood pressure swings, anxiety and tachycardia, and the effect may be unreliable because herbal content varies.
What this interaction means in plain words
Trazodone and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing adrenergic effects: yohimbine blocks alpha-2 receptors and increases sympathetic outflow, whereas trazodone has alpha-1 antagonism and serotonergic activity.
What to do
Advise patients to avoid yohimbe products while taking trazodone. If used, monitor blood pressure and heart rate and stop yohimbe if there is agitation, palpitations or blood pressure instability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Trazodone with Yohimbe?
MediHelp rates the interaction as moderate. Trazodone and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine, the active alkaloid in yohimbe, is an alpha-2 antagonist that raises noradrenergic activity and blood pressure, while trazodone blocks alpha-1 receptors and can lower it. Together they may cause unpredictable blood pressure swings, anxiety and tachycardia, and the effect may be unreliable because herbal content varies.
How serious is the interaction between Trazodone and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe products while taking trazodone. If used, monitor blood pressure and heart rate and stop yohimbe if there is agitation, palpitations or blood pressure instability.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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