Drug interactions
Trazodone + Yohimbine
Severity: Moderate
Trazodone and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that raises noradrenergic output, and trazodone has alpha-1 blocking and serotonergic activity. Together they can cause unpredictable blood pressure and heart rate changes, anxiety or agitation. The legacy tricyclic reuptake rationale does not fit trazodone well, so the evidence is limited.
What this interaction means in plain words
Trazodone and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing and additive effects on adrenergic and serotonergic signalling; the exact mechanism for this pair is not well established.
What to do
Avoid routine combined use where possible; if used, monitor blood pressure, heart rate and anxiety or agitation. Reduce or stop yohimbine if hypertension, tachycardia or serotonergic symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Trazodone with Yohimbine?
MediHelp rates the interaction as moderate. Trazodone and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that raises noradrenergic output, and trazodone has alpha-1 blocking and serotonergic activity. Together they can cause unpredictable blood pressure and heart rate changes, anxiety or agitation. The legacy tricyclic reuptake rationale does not fit trazodone well, so the evidence is limited.
How serious is the interaction between Trazodone and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combined use where possible; if used, monitor blood pressure, heart rate and anxiety or agitation. Reduce or stop yohimbine if hypertension, tachycardia or serotonergic symptoms appear.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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