Drug interactions
Trazodone + Zolpidem
Severity: Moderate
Trazodone and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating, and combined use can cause increased drowsiness, dizziness, orthostatic hypotension and psychomotor impairment. The combination is common for insomnia but increases risk of next-day impairment and falls.
What this interaction means in plain words
Trazodone and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trazodone belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A agonism (zolpidem) and 5-HT2A/H1/alpha-1 antagonism (trazodone).
What to do
Use the lowest effective doses, particularly in older adults, and warn about driving and activities needing alertness. Monitor for orthostatic dizziness and complex sleep behaviours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Trazodone with Zolpidem?
MediHelp rates the interaction as moderate. Trazodone and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating, and combined use can cause increased drowsiness, dizziness, orthostatic hypotension and psychomotor impairment. The combination is common for insomnia but increases risk of next-day impairment and falls.
How serious is the interaction between Trazodone and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, particularly in older adults, and warn about driving and activities needing alertness. Monitor for orthostatic dizziness and complex sleep behaviours.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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