Drug interactions
Treprostinil + Verapamil
Severity: Moderate
Treprostinil and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, so combining it with verapamil may cause additive hypotension. Treprostinil also inhibits platelet aggregation.
What this interaction means in plain words
Treprostinil and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Treprostinil belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Additive vasodilatory and blood pressure lowering effects.
What to do
Monitor blood pressure, particularly when starting or titrating treprostinil, and reduce the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Treprostinil with Verapamil?
MediHelp rates the interaction as moderate. Treprostinil and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator, so combining it with verapamil may cause additive hypotension. Treprostinil also inhibits platelet aggregation.
How serious is the interaction between Treprostinil and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, particularly when starting or titrating treprostinil, and reduce the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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