Drug interactions
Trimipramine + Triprolidine
Severity: Moderate
Trimipramine and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a sedating tricyclic with anticholinergic effects, so combining it with triprolidine increases drowsiness and anticholinergic effects such as dry mouth, constipation, urinary retention and confusion. Older adults are at highest risk.
What this interaction means in plain words
Trimipramine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trimipramine belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Monitor for oversedation and anticholinergic toxicity, especially in older or prostatic patients. Use a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Trimipramine with Triprolidine?
MediHelp rates the interaction as moderate. Trimipramine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a sedating tricyclic with anticholinergic effects, so combining it with triprolidine increases drowsiness and anticholinergic effects such as dry mouth, constipation, urinary retention and confusion. Older adults are at highest risk.
How serious is the interaction between Trimipramine and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity, especially in older or prostatic patients. Use a non-sedating antihistamine.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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