Drug interactions
Trimipramine + Umeclidinium bromide / vilanterol inhaled
Severity: Major
Trimipramine and Umeclidinium bromide / vilanterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of vilanterol, a long-acting beta agonist, including tachycardia, hypertension and QT prolongation. Umeclidinium adds to the anticholinergic burden, though systemic exposure is low.
What this interaction means in plain words
Trimipramine and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive adrenergic stimulation and QT prolongation, with additive anticholinergic effects.
What to do
Use only with caution and monitor heart rate, blood pressure and ECG where appropriate. Consider an alternative bronchodilator regimen in patients with cardiac disease or arrhythmia risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Trimipramine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as major. Trimipramine and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of vilanterol, a long-acting beta agonist, including tachycardia, hypertension and QT prolongation. Umeclidinium adds to the anticholinergic burden, though systemic exposure is low.
How serious is the interaction between Trimipramine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only with caution and monitor heart rate, blood pressure and ECG where appropriate. Consider an alternative bronchodilator regimen in patients with cardiac disease or arrhythmia risk.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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