Drug interactions
Trimipramine + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Trimipramine and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of inhaled vilanterol, including tachycardia, hypertension and QT prolongation. Systemic vilanterol exposure is low, but the effect may still be relevant in vulnerable patients.
What this interaction means in plain words
Trimipramine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation and QT prolongation.
What to do
Monitor heart rate, blood pressure and palpitations, and obtain an ECG in patients with cardiac risk factors. Consider an alternative inhaled regimen if cardiovascular effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Trimipramine with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Trimipramine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of inhaled vilanterol, including tachycardia, hypertension and QT prolongation. Systemic vilanterol exposure is low, but the effect may still be relevant in vulnerable patients.
How serious is the interaction between Trimipramine and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and palpitations, and obtain an ECG in patients with cardiac risk factors. Consider an alternative inhaled regimen if cardiovascular effects occur.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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