Drug interactions
Trimipramine + Yohimbe
Severity: Major
Trimipramine and Yohimbe: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine increases noradrenergic activity through alpha-2 blockade, while trimipramine can alter adrenergic tone. The combination may cause unpredictable blood pressure swings, tachycardia and agitation.
What this interaction means in plain words
Trimipramine and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive noradrenergic and adrenergic effects; predicted pharmacodynamically.
What to do
Avoid yohimbe products with trimipramine. Monitor blood pressure and heart rate if exposure occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Trimipramine with Yohimbe?
MediHelp rates the interaction as major. Trimipramine and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Yohimbine increases noradrenergic activity through alpha-2 blockade, while trimipramine can alter adrenergic tone. The combination may cause unpredictable blood pressure swings, tachycardia and agitation.
How serious is the interaction between Trimipramine and Yohimbe?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbe products with trimipramine. Monitor blood pressure and heart rate if exposure occurs.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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