Drug interactions
Trimipramine + Zolpidem
Severity: Moderate
Trimipramine and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a highly sedating tricyclic, and with zolpidem it can produce excessive sedation, confusion and impaired coordination. Anticholinergic effects and orthostasis from trimipramine add to the fall risk in older patients.
What this interaction means in plain words
Trimipramine and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trimipramine belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A agonism and strong H1-antihistaminic/anticholinergic effects of trimipramine.
What to do
Use the lowest effective doses and avoid in older adults where possible. Monitor for oversedation, confusion and next-day impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Trimipramine with Zolpidem?
MediHelp rates the interaction as moderate. Trimipramine and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a highly sedating tricyclic, and with zolpidem it can produce excessive sedation, confusion and impaired coordination. Anticholinergic effects and orthostasis from trimipramine add to the fall risk in older patients.
How serious is the interaction between Trimipramine and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid in older adults where possible. Monitor for oversedation, confusion and next-day impairment.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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