Drug interactions
Triptorelin + Vorinostat
Severity: Moderate
Triptorelin and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation, and triptorelin may also lengthen the QT interval. Using both may increase the risk of arrhythmia, especially with electrolyte disturbances.
What this interaction means in plain words
Triptorelin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Triptorelin belongs to Endocrine; Vorinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Perform a baseline ECG and correct potassium, magnesium and calcium. Repeat ECG periodically and reassess if QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triptorelin
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Triptorelin with Vorinostat?
MediHelp rates the interaction as moderate. Triptorelin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation, and triptorelin may also lengthen the QT interval. Using both may increase the risk of arrhythmia, especially with electrolyte disturbances.
How serious is the interaction between Triptorelin and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline ECG and correct potassium, magnesium and calcium. Repeat ECG periodically and reassess if QTc rises significantly.
What other medicines interact with Triptorelin?
MediHelp also lists interactions of Triptorelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Triptorelin page.
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