Drug interactions
Trofinetide + Valsartan
Severity: Minor
Trofinetide and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide may inhibit OATP1B1 and OATP1B3, which could raise valsartan plasma levels. The clinical effect is probably modest.
What this interaction means in plain words
Trofinetide and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Trofinetide belongs to Central Nervous System; Valsartan belongs to Cardiovascular.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake of valsartan.
What to do
Monitor blood pressure for excess lowering and adjust valsartan if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Trofinetide
Frequently asked questions
Can I take Trofinetide with Valsartan?
MediHelp rates the interaction as minor. Trofinetide and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trofinetide may inhibit OATP1B1 and OATP1B3, which could raise valsartan plasma levels. The clinical effect is probably modest.
How serious is the interaction between Trofinetide and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure for excess lowering and adjust valsartan if needed.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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