Drug interactions
Typhoid vaccine live + Vedolizumab
Severity: Moderate
Typhoid vaccine live and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine (Ty21a) colonizes the gut, where vedolizumab acts. Vedolizumab could reduce the vaccine response or permit prolonged replication of the vaccine strain, although systemic effects are limited.
What this interaction means in plain words
Typhoid vaccine live and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Vedolizumab blocks α4β7-mediated lymphocyte homing to the gut, theoretically altering local immune response to a live attenuated bacterium.
What to do
Use the inactivated injectable typhoid vaccine in patients on vedolizumab. Complete any live vaccination before starting therapy where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Frequently asked questions
Can I take Typhoid vaccine live with Vedolizumab?
MediHelp rates the interaction as moderate. Typhoid vaccine live and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine (Ty21a) colonizes the gut, where vedolizumab acts. Vedolizumab could reduce the vaccine response or permit prolonged replication of the vaccine strain, although systemic effects are limited.
How serious is the interaction between Typhoid vaccine live and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inactivated injectable typhoid vaccine in patients on vedolizumab. Complete any live vaccination before starting therapy where possible.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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