Drug interactions
Umeclidinium-vilanterol + Voclosporin
Severity: Moderate
Umeclidinium-vilanterol and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin may prolong the QT interval at supratherapeutic exposures, and vilanterol can also affect repolarization. Together they may increase arrhythmia risk, especially with electrolyte disturbance.
What this interaction means in plain words
Umeclidinium-vilanterol and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Umeclidinium-vilanterol belongs to Respiratory; Voclosporin belongs to Miscellaneous.
Why it happens
Additive effects on cardiac repolarization.
What to do
Monitor ECG in patients with QT risk factors and maintain normal potassium and magnesium. Review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Umeclidinium-vilanterol with Voclosporin?
MediHelp rates the interaction as moderate. Umeclidinium-vilanterol and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin may prolong the QT interval at supratherapeutic exposures, and vilanterol can also affect repolarization. Together they may increase arrhythmia risk, especially with electrolyte disturbance.
How serious is the interaction between Umeclidinium-vilanterol and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with QT risk factors and maintain normal potassium and magnesium. Review other QT-prolonging drugs.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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