Drug interactions
Umeclidinium-vilanterol + Ziprasidone
Severity: Major
Umeclidinium-vilanterol and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone carries a notable QT-prolonging effect, and vilanterol may add adrenergic cardiac stimulation and hypokalemia. This raises the risk of ventricular arrhythmias in susceptible patients.
What this interaction means in plain words
Umeclidinium-vilanterol and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Umeclidinium-vilanterol belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization and adrenergic stimulation.
What to do
Avoid if possible or monitor ECG and correct potassium and magnesium before and during co-therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Umeclidinium-vilanterol with Ziprasidone?
MediHelp rates the interaction as major. Umeclidinium-vilanterol and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ziprasidone carries a notable QT-prolonging effect, and vilanterol may add adrenergic cardiac stimulation and hypokalemia. This raises the risk of ventricular arrhythmias in susceptible patients.
How serious is the interaction between Umeclidinium-vilanterol and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or monitor ECG and correct potassium and magnesium before and during co-therapy.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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