Drug interactions
Vancomycin + Voclosporin
Severity: Moderate
Vancomycin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, is nephrotoxic, and vancomycin can also injure the kidney. Together they may increase the risk of acute kidney injury and reduced voclosporin tolerability.
What this interaction means in plain words
Vancomycin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vancomycin belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity from calcineurin inhibitor-induced afferent vasoconstriction and vancomycin tubular injury.
What to do
Monitor serum creatinine and eGFR closely, and check vancomycin levels. Reduce or interrupt voclosporin per labeling if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Vancomycin with Voclosporin?
MediHelp rates the interaction as moderate. Vancomycin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, is nephrotoxic, and vancomycin can also injure the kidney. Together they may increase the risk of acute kidney injury and reduced voclosporin tolerability.
How serious is the interaction between Vancomycin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR closely, and check vancomycin levels. Reduce or interrupt voclosporin per labeling if renal function declines.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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