Drug interactions
Vandetanib + Varenicline
Severity: Minor
Vandetanib and Varenicline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits OCT2, which mediates renal secretion of varenicline, and may increase varenicline exposure. This could heighten nausea, insomnia and neuropsychiatric effects.
What this interaction means in plain words
Vandetanib and Varenicline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Vandetanib belongs to Oncology; Varenicline belongs to Respiratory.
Why it happens
Vandetanib inhibits OCT2-mediated renal tubular secretion of varenicline.
What to do
Monitor for varenicline adverse effects such as nausea and sleep disturbance. Lower the varenicline dose if not tolerated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Varenicline
- Ethanol + Varenicline Moderate
- Tafenoquine + Varenicline Moderate
- Trilaciclib + Varenicline Moderate
- Cimetidine + Varenicline Minor
- Erdafitinib + Varenicline Minor
- Ibuprofen / famotidine + Varenicline Minor
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Vandetanib with Varenicline?
MediHelp rates the interaction as minor. Vandetanib and Varenicline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vandetanib inhibits OCT2, which mediates renal secretion of varenicline, and may increase varenicline exposure. This could heighten nausea, insomnia and neuropsychiatric effects.
How serious is the interaction between Vandetanib and Varenicline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for varenicline adverse effects such as nausea and sleep disturbance. Lower the varenicline dose if not tolerated.
What other medicines interact with Varenicline?
MediHelp also lists interactions of Varenicline with, for example, Ethanol, Tafenoquine, Trilaciclib. The full list is on the Varenicline page.
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