Drug interactions
Vardenafil + Voclosporin
Severity: Moderate
Vardenafil and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can prolong the QT interval, and vardenafil has a modest QT effect, so combined use may increase arrhythmia risk. The risk is higher with electrolyte abnormalities or heart disease.
What this interaction means in plain words
Vardenafil and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vardenafil belongs to Genitourinary; Voclosporin belongs to Miscellaneous.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check ECG and correct potassium and magnesium disturbances in at-risk patients. Use the lowest effective vardenafil dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Vardenafil with Voclosporin?
MediHelp rates the interaction as moderate. Vardenafil and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can prolong the QT interval, and vardenafil has a modest QT effect, so combined use may increase arrhythmia risk. The risk is higher with electrolyte abnormalities or heart disease.
How serious is the interaction between Vardenafil and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium disturbances in at-risk patients. Use the lowest effective vardenafil dose.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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