Drug interactions
Vardenafil + Zafirlukast
Severity: Minor
Vardenafil and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast is only a weak CYP3A4 inhibitor, so it may modestly raise vardenafil exposure. The clinical impact is expected to be small but could increase vasodilatory adverse effects such as hypotension, headache or flushing.
What this interaction means in plain words
Vardenafil and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Vardenafil belongs to Genitourinary; Zafirlukast belongs to Respiratory.
Why it happens
Weak inhibition of CYP3A4-mediated vardenafil metabolism by zafirlukast (predicted from in vitro data).
What to do
No routine dose change is needed; counsel the patient to report dizziness or symptomatic hypotension. Use the lowest effective vardenafil dose in patients who are sensitive to hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Vardenafil with Zafirlukast?
MediHelp rates the interaction as minor. Vardenafil and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast is only a weak CYP3A4 inhibitor, so it may modestly raise vardenafil exposure. The clinical impact is expected to be small but could increase vasodilatory adverse effects such as hypotension, headache or flushing.
How serious is the interaction between Vardenafil and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; counsel the patient to report dizziness or symptomatic hypotension. Use the lowest effective vardenafil dose in patients who are sensitive to hypotension.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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