Drug interactions
Varicella virus vaccine live + Vedolizumab
Severity: Moderate
Varicella virus vaccine live and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Varicella vaccine is a live attenuated vaccine that can cause disseminated disease in immunocompromised people. Vedolizumab's immune effects are mostly gut-selective, so risk is likely low, but labeling advises avoiding live vaccines unless benefit outweighs risk.
What this interaction means in plain words
Varicella virus vaccine live and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical reduced immune control of live attenuated varicella virus during vedolizumab therapy.
What to do
Check varicella immunity and vaccinate before starting vedolizumab where possible. If already on therapy, vaccinate only if benefit outweighs risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Frequently asked questions
Can I take Varicella virus vaccine live with Vedolizumab?
MediHelp rates the interaction as moderate. Varicella virus vaccine live and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Varicella vaccine is a live attenuated vaccine that can cause disseminated disease in immunocompromised people. Vedolizumab's immune effects are mostly gut-selective, so risk is likely low, but labeling advises avoiding live vaccines unless benefit outweighs risk.
How serious is the interaction between Varicella virus vaccine live and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check varicella immunity and vaccinate before starting vedolizumab where possible. If already on therapy, vaccinate only if benefit outweighs risk.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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